Best utilizing fat long pipes and large file transfer

[sean at craigslist.org (Sean Knox)]

Hi,

I'm looking for input on the best practices for sending large files over 
a long fat pipe between facilities (gigabit private circuit, ~20ms RTT).
I'd like to avoid modifying TCP windows and options on end hosts where 
possible (I have a lot of them). I've seen products that work as 
"transfer stations" using "reliable UDP" to get around the windowing 
problem.

I'm thinking of setting up servers with optimized TCP settings to push 
big files around data centers but I'm curious to know how others deal 
with LFN+large transfers.

thanks,
Sean